Publications
Selected publications
1. Li, Z. and Ngan, E.S.* 2022 New insights empowered by single-cell sequencing: from neural crest to enteric nervous system. Computational and Structural Biotechnology Journal. 20 (2022) 2464–2472 iF: 6.155 [Pubmed]
​
2. Lai, F.P.L., Li, Z., Zhou, T., Leung, A.O.W., Lau, S.T., Lui, K.N.C., Wong, W.Y.M., Sham, P.C., Hui, C.C., Ngan, E.S.* 2021 Ciliary protein Kif7 regulates Gli and Ezh2 for initiating the neuronal differentiation of enteric neural crest cells during development. Science Advances 2021 Oct 15;7(42):eabf7472 . IF:14.957 [Pubmed]
3. Fu AX, Lui KN, Tang CS, Ng RK, Lai FP, Lau ST, Li Z, Garcia-Barcelo MM, Sham PC, Tam PK, Ngan ES, Yip KY. Whole-genome analysis of noncoding genetic variations identifies multiscale regulatory element perturbations associated with Hirschsprung disease. Genome Res. 2020 Nov;30(11):1618-1632 IF: 9.944 [Pubmed]
4. Lau ST, Li Z, Lai FPL, Lui KNC, Li P, Munera JO, Pan G, Mahe MM, Hui CC, Wells JM, Ngan, E.S.* Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on single-cell Transcriptome Analyses. Gastroenterology 2019 Dec;157(6):1556-1571.e5. IF: 20.77 [Pubmed)
5. Yin, W.C., Satkunendran, T., Mo, R., Morrissy, S., Zhang, X., Uusküla-Reimand, L., Hou, H., Huang, E. S., Liu, W., Liu, Y.C., Zhang, J., Parker, J., Wang, X., Farooq, H., Selvadurai, H., Chen, X. , Ngan, E.S., Cheng, S.Y., Dirks, P.B., Angers, S., Wilson, M.D., Taylor, M.D., Hui, C.C. 2018 Dual regulatory functions of SUFU and targetome of GLI2 in SHH medulloblastoma. Dev Cell, 48(2):167-183.e5. IF: 9.19 [Pubmed)
4. Tang, C.S., Li, P., Lai, F.P., Fu, A.X., Lau, S.T., So, M.T., Lui, K.N.C., Li,Z., Zhuang, X., Yu, M., Liu, X., Ngo, N.D., Miao, X., Zhang, X., Yi, B., Tang, S., Sun, X., Zhang, F., Liu, H., Liu, Q., Zhang, R., Wang, H., Huang, L., Dong, X., Tou, J., Cheah, K.S.E., Yang, W., Yuan, Z., Yip, K.Y.L., Sham, P.C., Tam, P. K.H., Garcia-Barcelo, M.M., Ngan, E.S.* 2018 Identification of Genes Associated with Hirschsprung Disease, Based on Whole-genome Sequence Analysis, and Potential Effects on Enteric Nervous System Development. Gastroenterology 2018 Sep 11. pii: S0016-5085(18)34965-5. IF: 20.77 [Pubmed]
5. Lai, F.P., Lau, S.T., Wong, J.W, Gui, H., Wang, X.R., Zhou, T., Lai, W.H., Tse, H.F., Tam, P.K., Garcia-Barcelo, M.M., Ngan, E.S.* Correction of Hirschsprung-associated Mutations in Human Induced Pluripotent Stem Cells, via CRISPR/Cas9, Restores Neural Crest Cell Function. 2017 Gastroenterology. 153(1):139-153.e8. IF: 20.77 [Pubmed]
6. Liu JA, Lai FP, Gui H, Sham MH, Tam PK, Garcia-Barcelo MM, Hui CC, Ngan ES.* 2015. Identification of GLI Mutations in Patients with Hirschsprung Disease That Disrupt Enteric Nervous System Development in Mice. Gastroenterology. 2015 1837-1848.e5. IF: 20.77 [PubMed]
7. Lau ST, Hansford LM, Chan WK, Chan GC, Wan TS, Wong KK, Kaplan DR, Tam PK, Ngan ES.* Prokineticin signaling is required for the maintenance of a de novo population of c-KIT+ cells to sustain neuroblastoma progression. Oncogene 2015 34: 1019-1034. IF: 8.559 [PubMed]
8. Shum CK, Lau ST, Tsoi LL, Chan LK, Yam JW, Ohira M, Nakagawara A, Tam PK, Ngan ES.* Kruppel-like factor 4 (KLF4) suppresses neuroblastoma cell growth and determines non-tumorigenic lineage differentiation. Oncogene 2013 32(35):4086-99. IF: 8.559 [PubMed]
9. Ngan ES*, Garcia-Barceló MM, Yip BH, Poon HC, Lau ST, Kwok CK, Sat E, Sham MH, Wong KK, Wainwright BJ, Cherny SS, Hui CC, Sham PC, Lui VC, Tam PK. Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. J Clin Invest. 2011; 121(9):3467-78. IF:15.387 [PubMed].
10. Ngan ES*, Lang BH, Liu T, Shum CK, So MT, Lau DK, Leon TY, Cherny SS, Tsai SY, Lo CY, Khoo US, Tam PK, Garcia-Barceló MM. A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma. J Natl Cancer Inst. 2009; 101(3):162-75. IF: 15.678 [PubMed]
11. Garcia-Barcelo MM, Tang CS, Ngan ES, Lui VC, Chen Y, So MT, Leon TY, Miao XP, Shum CK, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KM, Wong KK, Cherny SS, Sham PC, Tam PK. Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease. Proc Natl Acad Sci U S A. 2009; 106(8):2694-9. IF:9.77 [PubMed]
12. Ngan ES*, Sit FY, Lee K, Miao X, Yuan Z, Wang W, Nicholls JM, Wong KK, Garcia-Barcelo M, Lui VC, Tam PK. Implications of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression. Clin Cancer Res. 2007; 13(3):868-75. IF:8.193 [PubMed]
13. Ngan ES, Hashimoto Y, Ma ZQ, Tsai MJ, Tsai SY. Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Oncogene. 2003; 22(5):734-9. IF 8.559 [PubMed]
14. Ngan ES, Ma ZQ, Chua SS, DeMayo FJ, Tsai SY. Inducible expression of FGF-3 in mouse mammary gland. Proc Natl Acad Sci U S A. 2002; 99(17):11187-92. IF 9.77 [PubMed]