Development of enteric nervous system

Molecular basis of the enteric nervous system development and Hirschsprung (HSCR) disease

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Enteric nervous system (ENS) in mammals is derived from the enteric NCCs. These precursor cells extensively proliferate to expand, migrate over a long distance to fully colonize the developing gut, and differentiate into millions of neuron and glia which are organized into the network to coordinate the complex behaviors of the gut. Failure of the enteric NCCs to form ganglia in the hindgut may result in HSCR.